In 2010, Winstead co-starred opposite Michael Cera in the comic-book adaptation Scott Pilgrim vs. The World, under the direction of Edgar Wright. The film sported an ensemble cast that includes Chris Evans, Brandon Routh, Anna Kendrick, Jason Schwartzman, Kieran Culkin, Aubrey Plaza and Johnny Simmons. Filming occurred from March to August 2009. For her role, Winstead went through fight training for two months and performed most of her own stunts. The film was released in 2010 to critical acclaim but lackluster box office returns, though it did considerably well once released to DVD. Winstead's performance was received generally well, and snagged her a Teen Choice Awards nomination for Choice Actress Action.
In February 2010, Winstead was cast in the lead role as paleontologist Dr. Kate Loyd in the prequel to The Thing, which was directed by Matthijs van Heijningen Jr. The movie was released October 14, 2011. Winstead stated that there was no romantic subplot for her character as she felt it would be out of place in the context of the film. Winstead based her performance on her sister, a neurologist. Critics singled out Winstead for praise in her performance as the lead. "[Winstead] stands out with her portrayal of a paleontologist.
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